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Thursday, November 23, 2023

CBD oil as a base for therapeutics

Hemp has been a friend of mankind since it was written down. It provides fiber from stems, nutrients from seeds, roots to flowers, and we get medicine from it. Marijuana has a very rich history as a drug, in many different cultures, including the United States, over thousands of years. In the second half of the 19th century, marijuana tinctures were an important part of America’s medicine cabinet. But because of taboos, we have lost touch with plants when it comes to healing. A federal ban was implemented in 1937, and it continues today. And because of the illegal status of marijuana and hemp, we have lost our understanding of how our ancestors and ancestors used the plant therapeutically.

The Basics of CBD

What we hope to do in this article is to focus very pragmatically on how best to use these hemp oils with different ratios of CBD and THC. How we use CBD for maximum therapeutic benefit. So let’s step back and look at some basic facts about CBD (also known as cannabidiol).

CBD is a phytocannabinoid. Here are the molecules and compounds in the cannabis plant. The same goes for THC. They are all cannabinoids. CBD is not psychoactive like THC. Taking it will not make you feel high.

The discovery of the cannabinoids CBD and THC

In 1940, American scientist Roger Adams discovered CBD. He first identified CBD as part of the cannabis plant, but it wasn’t until 1963 that Dr. Doctor elucidated its molecular structure. Israeli scientist Raphael Mechoulam did the same for THC the following year. CBD has amazing therapeutic potential, and that’s what we’re going to focus on. Not just single molecules, but whole plants.

When CBD is first molecularly identified and its configuration understood , it doesn’t necessarily immediately spark a flood of research on CBD’s therapeutic potential. The emphasis is more on THC as this can make a person tall or addicted. So this is where more research funding (in the range available in the 60s) is concentrated.

But in Israel and Brazil, mainly in these two countries, there are a few different clinical studies scattered. In 1980, there was a study involving about a dozen people, mostly children, which showed that cannabinoids have a huge role in reducing seizures. So, long ago, CBD made a splash for its seizure control properties , which are anticonvulsant properties.

Cannabinoids are very potent neuroprotectants and antioxidants

Fast forward to 1988. A study was published that year, which was funded by the National Institutes of Health, and identified the phytocannabinoids THC and CBD as very potent neuroprotectants and antioxidants. And these compounds have the ability to neutralize the damaging effects of free radicals on the human body. Therefore, it will protect neurons. Due to the antioxidant effect, brain cells are protected from degeneration.

This forms the basis for the federal government to actually obtain patents at night. The patent was filed in 2003 and is today misunderstood as a CBD patent. It’s not just a patent on CBD, it’s largely based on research on THC and CBD, so CBD and THC and phytocannabinoids in general are a patent.

Scientifically identified properties of CBD and THC

Both CBD and THC are scientifically proven to produce or trigger neurogenesis. This means the creation of new brain cells in adult mammals. And going back about 30 years ago, that was considered impossible. It was once thought that once brain cells were damaged, they would never regenerate.

Well, now we have a new paradigm in brain science, and research on cannabinoids proves it again. As far as the properties of CBD are concerned, it has been studied quite extensively as a single molecule by scientists all over the world.

It is shown to have:

  • Antitumor properties
  • antispasmodic properties
  • Anticonvulsant properties
  • Antidepressant Properties
  • Antipsychotics
  • Anti-addictive properties

Additionally, it is considered an anxiolytic, reduces anxiety, has been shown to have antibiotic properties, and is an analgesic (pain reliever). This is just single-molecule CBD, which has been shown in laboratory experiments.

Interaction of cannabinoids with isolated cannabinoids

But we’re going to focus on CBD for the entire plant. We’ll look at the differences between individual molecules and whole plant CBD. The first thing to emphasize when it comes to cannabis therapy is that CBD and THC work best together. They have a synergistic relationship. If you want to get the most therapeutic benefit from using these compounds, you should think of them as working in tandem.

A person can use single-molecule THC, which is available by prescription today and is legally available by prescription in all 50 U.S. states. However, we will look at the synergy between them and how they enhance each other’s effects.

CBD is known to actually enhance the pain-relieving effects of THC . In addition to preclinical studies, this is also demonstrated in the sense of actual clinical studies. CBD is known to increase the efficiency or efficacy of cannabis in the treatment of neuropathic pain, autoimmune diseases, cancer and other diseases.

Cannabinoids expand the range of diseases that cannabis can treat

When CBD and THC are together, they work better under these conditions. Likewise, once CBD is part of the picture, it becomes part of the grassroots mix, after the grassroots field is ignored because the focus is getting higher and higher.

After the re-emergence of CBD as part of grassroots blends in Northern California starting in 2009 and people starting to use it as part of CBD-enriched cannabis preparations, we have seen very clearly that CBD can actually expand the use of non-cannabis cannabis. Such a response must be made to the main remedy for THC.

We’re talking about liver disease, cardiovascular disease, and metabolic abnormalities. This is an example of the synergy with CBD and THC from a 2010 scientific study conducted at the Pacific Medical Center in California. Here’s how CBD amplifies the inhibitory effects of THC on brain cancer. 

The actual summary is:

CBD enhances the inhibitory effect of delta 9 THC on human glioblastoma cell proliferation and survival. Studies have shown that THC alone has anticancer/antitumor properties. As far as these brain cancer experiments are concerned, there is only CBD. However, when they are combined, the effect is stronger than either one alone.

The psychoactive properties of cannabinoids

It is important to remember that CBD is not psychoactive like THC. Now, many people are very fond of marijuana. Others find THC unpleasant. It makes them anxious, paranoid, no matter why they don’t like the experience. The good news is that using CBD can reduce or neutralize high THC, depending on the amount of each compound in a given strain or product. This means that a higher ratio of CBD to THC means a higher price.

Now you have strong medical marijuana programs in some states where the CBD to THC ratio of cannabis oil concentrates is different. Therefore, patients can use them and adjust the ratio between THC and CBD and adjust the dosage. Mental activity can actually be eliminated entirely if they wanted to. High effects can be removed if they are not satisfied. They can find the right level of mental activity that suits their needs and sensitivities. So patients can choose.

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